Northern Arizona University built the Biology and Biochemistry Building in 2000. The architecture is postmodern, as evidenced by the neoclassical columns and polychrome facades. The facility houses four teaching and ten research laboratories, a 254-seat lecture hall, offices, and a conference room. The building also contains the Imaging and Histology Core Facility, which houses multiple high powered microscopes. The structure has a sky bridge linking it to the Chemistry Building.
In 2001, the University dedicated the building in honor of John F. Wettaw. He joined NAU's Chemistry department in 1967 and continued teaching until his retirement in 2014. He also served in the Arizona House of Representatives for twenty years and the state Senate for eight, holding the record for the longest-serving Republican state legislator in Arizona.